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The supply pathway involves the export of GSH from astrocytes via the multidrugresistance protein 1 (Mrp1), extracellular processing of GSH by astrocytic glutamyl transpeptidase (GT) to the dipeptide cysteinylglycine (CysGly) and hydrolysis of this dipeptide by neuronal aminopeptidase N (ApN) to cysteine (Cys) and glycine (Gly)

It modulates nitric oxide systems to improve local blood flow, delivering more nutrients to damaged tissue

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Dihexa, chemically known as N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, emerged from efforts to create a small molecule that retains the memory-enhancing properties of Nle-AngIV and its N-terminal fragments

128,129 Xian et al